From chemistry-request@www.ccl.net Fri Jan 17 18:17:00 EST 1997
Date: Fri, 17 Jan 1997 10:46:36 +0100
To: chemistry@www.ccl.net
From: netsci@awod.com (Network Science)
Subject: 97.03.03 Advancing New Lead Discovery
The final program for The 1997 Charleston Conference is reproduced below:
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The 1997 Charleston Conference
Advancing New Lead Discovery
March 3-5, 1997
Wild Dunes Resort
Isle of Palms, South Carolina
[ ========================================================= ]
At one time, pharmaceutical scientists studied the function and structure
of a novel biological target and spent years identifying and optimizing a
lead candidate. Over the past few years, competitive pressures have forced
research to become more efficient. Emerging new technologies such as
genomics, gene sequencing, transgenic animals, and molecular biology have
afforded large numbers of novel, clinically relevant biological targets.
High throughput screening and combinatorial chemistry have been used to
rapidly identify and optimize leads for these targets. Additionally, the
complementary techniques of computational chemistry and cheminformatics
have been used to successfully leverage research information.
The invited lectures and round-table discussions to be held over two and
one-half days will focus on the successful integration of these
technologies in new lead discovery and development. Participants will
explore the ways in which the industry is increasing the productivity of
the discovery process. The outstanding group of invited session chairs and
speakers who will lead the meeting are listed below.
Monday, March 3
Opening Address
8:30 - 9:30 Gerald Maggiora
Director, Computer-Aided Drug Discovery
Pharmacia & Upjohn
Title: Data Information and Knowledge Flow in Discovery
Research
Bioinformatics
Session Chair: Michael N. Liebman
Director, Bioinformatics and Genomics
Vysis, Inc.
9:30 - 10:30: Michael W. Retsky
Associate Professor, University of Colorado and
Scientific Director, OncoMetics, Inc.
Title: Computer Model Predicts Long-term Maintenance
Chemotherapy is Possible in Breast Cancer: Clinical
Trial at Five Year Point
10:30 - 11:30: Frank Tobin
Assistant Director, Scientific Computing Consulting
SmithKline Beecham
Title: Phenomenologically Modeling Disease: Tumor
Heterogeneity and Progression
11:30 - 12:30: Michael N. Liebman
Director, Bioinformatics and Genomics
Vysis, Inc.
Title: Qualitative Reasoning About Disease Processes: An
Integrated Perspective
Lunch Break
Combinatorial Chemistry
Session Chair: Michael Pavia
Vice President, Cambridge Research
Sphinx Pharmaceuticals, A Division of Eli Lilly and Company
1:30 - 2:30: William Hoekstra
Principal Scientist
RW Johnson Pharmaceutical Research Institute
Title: Solid Phase Parallel Synthesis: Lead Development
of Novel Receptor Antagonists
2:30 - 3:30: Stephen W. Kaldor
Head, Combinatorial Chemistry
Lilly Research, Eli Lilly and Company
Title: Drug Discovery Using Combinatorial Chemistry:
From the Test Tube to the Clinic
3:30 - 4:30: Peter Myers
Chief Operating Officer
CombiChem, Inc.
Title: A Rapid and Reliable Methodology for Drug
Discovery Using Informative Compound Libraries
4:30 - 5:30: Alex Polinsky
Vice President and Chief Scientific Officer
Alanex Corporation
Title: Integration of Combinatorial Chemistry into the
Drug Discovery Process
Dinner: A Taste of Charleston (Sponsored by Network Science Corporation)
Tuesday, March 4
High Throughput Screening
Session Chair: John P. Devlin
President and Chief Executive Officer
ARRT International and MicroBotanica, Inc.)
9:00 - 10:00: John Babiak
Associate Director, Robotics and Automation
Wyeth-Ayerst Research Institute
Title: Positive Impacts of Automation on the Drug
Discovery Process
10:00 - 11:00: Jonathan Cook
Technical Manager, High Throughput Screening Group
Procter & Gamble Pharmaceuticals
Title: Establishing High Throughput Screening Core
Facility at Procter & Gamble Pharmaceuticals
11:00 - 12:00: Harry Stylli
Senior Director, Screening Technologies
Aurora BioSciences
Title: An Integrated Approach to Ultra High Throughput
Screening: From Gene to Lead
Lunch Break
Computational Chemistry
Session Chair: Christine Humblet
Senior Director, Biomolecular Structure and Drug Design
Section
Parke-Davis Research, Warner-Lambert
1:00 - 2:00: Bob McDowell
Senior Scientist
Genentech
Title: Structure-Based Design From Protein-Protein
Interfaces: New Paradigm or Fools Errand
2:00 - 3:00: Dennis Underwood
Associate Director, Molecular Systems
Merck Research Laboratories
Title: G-Protein Coupled Receptors: Agonism and
Antagonism
3:00 - 4:00: Jean-Pierre Wery
Head, Computational Chemistry and Molecular Structure
Research
Lilly Research Laboratories, Eli Lilly and Company
Title: Design of Potent and Selective Inhibitors of
Human Non-Pancreatic Secretory Phospholipase A2
4:00 - 5:00: Scott Dixon
Associate Director
SmithKline Beecham Pharmaceutical Research and
Development
Title: Perspectives on the Direction of Docking,
Databases and Diversity
Wednesday, March 5
Cheminformatics
Session Chair: Allen B. Richon
Vice President and Chief Science Officer
Network Science Corporation
9:00 - 10:00: Jon S. Mason
Head, Computer-Assisted Drug Design
Rhone-Poulenc Rorer, Inc.
Title: Aspects of Pharmacophoric Diversity
10:00 - 11:00: Robert S. Pearlman
Professor, College of Pharmacy
University of Texas at Austin
Title: Novel Software for Combinatorial Chemistry &
Chemical Diversity
11:00 - 12:00: David Spellmeyer
Associate Director, Computational and Biophysical
Chemistry Group
Chiron Corporation
Title: Computational Approaches to Combinatorial
Libraries
Close of the Conference
Accommodations
The Wild Dunes conference center offers a variety of activities including
two world class golf courses, several tennis courts, and a heated pool.
Housing will be available beginning Saturday, March 1. To facilitate a
lively exchange of ideas with colleagues in a casual setting, attendance at
this meeting will be limited. Please use the form below to submit your
registration.
Housing for the meeting is available in the Boardwalk Villas at the Grand
Pavilion. These turn-of-the-century style homes, feature an open area
(entrance, balcony, living room, kitchen, dining room, washer and dryer)
and three completely private rooms each of which is accessed by a central
staircase. All rooms include separate key entry, private bath, individual
phone line with voice mail, cable television and a coffee maker. Network
Science has reserved a block of these rooms at a special conference rate of
$79/night plus tax and service charges. Special rental arrangements can be
made for attendees traveling with families.
Other Information
Payments: The conference registration fee is $895 ($695, academic). This
includes all breakfasts, lunches, refreshments, and the conference
workbook. Payments should be in the form of personal or company check made
payable to Network Science Corporation (EIN: 57-1038302).
Accommodations: Registration forms must be completed to reserve conference
space. A limited block of rooms has been reserved with the conference
center at a special discounted rate for attendees. To secure your
accommodations, please remit a deposit equivalent to one night's rate with
your registration fee. The single-room discounted rate is $79 per night
plus taxes and service charges. Three bedroom ($237/night plus taxes and
service charges) and four bedroom ($316/night plus taxes and service
charges) houses are available for families. Contact Network Science if you
have any questions (E-mail: netsci@awod.com).
Cancellations: All cancellations will be subject to a $200 administration
fee. In order to receive a prompt refund, your notice of cancellation must
be received in writing (by letter or fax). The registration may be
transferred to another member of your organization for attendance at this
meeting. In the event of a conference cancellation, Network Science
Corporation assumes no liability for non-refundable transportation costs,
hotel accommodations or additional costs incurred by registrants.
[===========================================================]
Registration Form
Meeting and Housing
Please Note: This electronic form will reserve your space at the Charleston
Conference. In order to guarantee your reservation, please send your
payment and registration form to Network Science at:
Network Science Corporation
412 Carolina Blvd.
Isle of Palms, SC 29451
Tel: 803-886-8775
Fax: 803-886-5924
E-mail: netsci@awod.com
Registration Form
Meeting and Housing
Name: ___________________________________________________________
Title: __________________________________________________________
Department: _____________________________________________________
Company: ________________________________________________________
Address: ________________________________________________________
________________________________________________________
City: ____________________________ State: _____ Code: __________
Country: _________________________
Phone: _________________________ Fax: ______________________
Home Phone: _______________________________
E-mail address: ___________________________
Arrival Date (check in 4:00 p.m.) ________________________
Departure Date (check out 11:00 a.m.) _____________________
Do you need shuttle service from the airport to Wild Dunes?
Arrival Time: _______________________________
Number of people in your party: _______________________
Registration fee:
Commercial ($895) _____
Academic ($695) _____
Please select your choice of accommodations from the options listed below:
Type of Unit Rate per Night Selection
Boardwalk Room single or double $79.00** _____
3 Bedroom Boardwalk Home $237.00** _____
4 Bedroom Boardwalk Home $316.00** _____
**Plus 6% South Carolina State Sales Tax, 5% South Carolina Accommodations
Tax and a 15% Service Charge
All accommodations require a three night minimum stay. A deposit equal to
one night's stay ($79, $237, or $316) is due with registration to secure
your reservation. All reservations should be made as early as possible in
order to guarantee specific accommodations and group rates. Please note
that Wild Dunes is comprised of privately owned villas; therefore, bedding
arrangements are not standardized as in hotels. Boardwalk suites are
comprised of three or four bedrooms. If you wish to share a suite with
colleagues, please include their names and affiliations.
Colleague Affiliation
______________________________ ______________________________
______________________________ ______________________________
______________________________ ______________________________
Your advance deposit will be applied to your account or be returned with 14
days notice should cancellation be necessary. Should you cancel less than
14 days before arrival, or fail to cancel a reservation, your one night's
deposit will be forfeited.
If you have any questions about the meeting that you would like to have
answered before you register, please use this e-mail link and give us you
name, e-mail address, telephone number, and question. We will contact you
as quickly as possible.
If it is more convenient, please print this registration form and FAX it to
Network Science at (803)886-5924 or mail it to:
Network Science Corporation
412 Carolina Blvd
Isle of Palms, SC 29451
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