From rlr@acsu.buffalo.edu  Thu Sep  9 14:12:23 1993
Date: Thu, 9 Sep 1993 18:12:23 -0400
From: "Raymond L. Roskwitakski" <rlr@acsu.buffalo.edu>
Message-Id: <199309092212.SAA23359@autarch.acsu.buffalo.edu>
To: CHEMISTRY@ccl.net
Subject: Measuring void 


Hello

  We have a hole (or void) in a protein which enters into the
active site. Would like to 
determine its size quantatively, and compare it with various 
substrates to decide if the substrates, at a fixed conformation 
are too big to enter.
Has anyone made or come across a quick and dirty method without
having to perform extensive docking.  

Ray

rlr@autarch.acsu.buffalo.edu