Automatic Analogue Proposal (Summary)

[Kestutis Sliupas <kestas $#at#$ ccl.net>]

 Hi:
 	I posted the following message, and received two fax's from
 vendors, Tripos and Bio-Sym. They are sending literature; however, I
 am really surprised that no users dropped a line. Perhaps it was the
 US holidays? When the lit. arrives, I will filter and post a summary.
 As an aside, does anyone know how to contact Dr. Marsili, the author
 of ANALOG, or obtain a copy for evaluation?
 Forwarded message:
 > Hi:
 > 	What programs are being used to suggest analogues of
 > lead compounds for biological evaluation? I personally am aware
 > of 'ANALOG' by Dr. M. Marsili, as described in a recent issue
 > of 'The Journal of Chemical Information and Computer Sciences',
 > but I am sure there must be several more.
 > 	What is their availability (ie. public domain, commercial),
 > strengths and weaknesses, ease of use, and requirements for input/output
 > formats? What is their general utility? Do they save time and money on
 > synthesis? Do they do an adequate job on proposing sufficiently diverse
 > analogues needed for a first-pass to explore the chemical and physical
 > parameters needed for bio. activity, or are they an interesting excercise?
 > 	Please reply via e-mail. I will summarise in a couple of
 > weeks.
 --
  				Regards, Kestas
   Kestutis Sliupas              x  (510) 231-1540 (work voice)
   kestas%lith.UUCP $#at#$ ucdavis.edu  x  (510) 231-1285 (work FAX) USA CA