From Don_Gregory@MSI.COM Sun Jun 12 12:40:42 1994 Received: from schizoid.msi.com for Don_Gregory@MSI.COM by www.ccl.net (8.6.4/930601.1506) id MAA28265; Sun, 12 Jun 1994 12:15:19 -0400 Received: from msi.com (qmail-gw.msi.com) by schizoid.msi.com (4.1/SMI-4.1) id AA13403; Sun, 12 Jun 94 12:14:53 EDT Message-Id: <9406121614.AA13403@schizoid.msi.com> Date: 12 Jun 1994 12:18:51 +0000 From: "Don Gregory" Subject: Drug Design Seminar Serius To: "OSC BBS" Subject: Time:10:00 AM OFFICE MEMO Drug Design Seminar Serius Date:6/10/94 Seminar Announcements! Announcing a free scientific seminar series presented by Molecular Simulations Inc. (MSI) and Hewlett Packard. Speakers for this program will discuss innovative scientific methods for structure activity analysis to enable users to increase the efficiency of the lead optimization and lead generation cycle in your organisation.. Topics will include: o Pharmacophore model generation o Database search strategies o Advanced QSAR techniques o Computer-aided compound selection o Molecular similarity o Pseudo-receptor model generation Coupling MSI's state-of-the-art modelling environment with the computational speed of Hewlett Packard's PA-RISC 7150 micro-processor, Hewlett Packard and MSI offer a complete solution that is fast, affordable, and easy to use. The series 700 model 735 workstation with the 7150 microprocessor running on 125mhz with performance up to 154MIPS, is ideal for compute intensive and demanding graphics applications. To register for any of the following seminars, call Molecular Simulations Inc. at (617) 229-9800, extension 567 in the U.S. In Europe, call +44 223 413302, extension 31. MOLECULAR SIMULATIONS INC. AND HEWLETT PACKARD PRESENT: STRATEGIES IN DRUG DISCOVERY SEMINAR SERIES IN THE U.S. Monday, July 18 Cambridge, MA Tuesday, July 19 New Brunswick, NJ Wednesday, July 20 Research Triangle Park, NC Thursday, July 21 La Jolla, CA Friday, July 22 Burlingame, CA (San Francisco Airport area) THE AGENDA 8:00am Registration and Continental Breakfast 8:30am Introduction and Welcome 8:45am Dr. Anthony Hopfinger, University of Illinois "Strategies for the Construction of 3D QSARs Based upon Molecular Shape Analysis" 9:30am Dr. David Rogers, Molecular Simulations Inc. "QSAR Analysis using Genetic Algorithms" 10:15am Product Demonstration 10:30am Coffee Break 10:45am Dr. Peter Sprague, BioCAD Corporation "Structure Activity Analysis with Catalyst: Conversion of Peptide Lead Information into Non-peptide Drug Candidates" 11:30am Dr. Simon Kearsley, Merck Research Laboratories "Computer-Aided Compound Selection Techniques" 12:15pm Product Demonstration ================================= STRATEGIES IN DRUG DISCOVERY SEMINAR SERIES IN EUROPE Tuesday, 28 June Stockholm, Sweden Wednesday, 29 June Paris, France Thursday, 30 June Frankfurt, Germany Friday, 1 July London, England AGENDA 9:30am Registration and Coffee 10:00am Introduction and Welcome 10:15am Dr. Anthony Hopfinger, University of Illinois "Strategies for the Construction of 3D QSARs Based upon Molecular Shape Analysis" 11:00am Dr. David Rogers, Molecular Simulations Inc. "QSAR Analysis using Genetic Algorithms" 11:45pm Product Demonstration 12:00pm Lunch 13:00pm Dr. Peter Sprague, BioCAD Corporation "Structure Activity Analysis with Catalyst: Conversion of Peptide Lead Information into Non-peptide Drug Candidates" 14:00pm Dr. Simon Kearsley, Merck Research Laboratories "Computer-Aided Compound Selection Techniques" 15:00pm Product Demonstration THE SPEAKERS Dr. Anthony Hopfinger - Dr. Hopfinger is Professor of Medicinal Chemistry, Chemistry and Chemical Engineering at the University of Illinois at Chicago. He received his Ph.D. from Case Western Reserve University, and was an NIH post-doctoral fellow at Harvard Medical School. Following post-doctoral studies, Dr. Hopfinger was a member of the faculty at Case Western Reserve University. In 1981 he joined G.D. Searle and Company as Director of Medicinal Chemistry, and in 1985 he took up his current position. Professor Hopfinger has over 185 publications including three books, and is co-founder of three companies focused on computational chemistry software and biotechnology. Dr. Peter W. Sprague - Dr. Sprague was educated (BS, PhD) in synthetic organic chemistry at Case-Western Reserve University and held acadmic positions at Indiana Universityand California State University at San Bernardino. He joined Bristol-Myers Squibb in 1972 and was involved with various medicinal chemistry projects including ACE inhibition and Thromboxane Antagonism until leaving in 1991 to join BioCAD Corporation where he currently holds the position of Vice President for Support. Dr. Simon Kearsley - Dr. Kearsley is currently a Senior Research Fellow at Merck Research Laboratories in charge of developing scientific computing methodology relevant to drug design. He earned his Ph.D. in Physical Chemistry from Cam-bridge University in England working with Professor Thomas. Dr. Kearsley also did post-doctoral work at Yale University with Professors McBride and Prestegard. Dr. David Rogers - Dr. Rogers joined MSI in 1991, and is currently leading the development of several applications based upon Genetic Algorithms. He earned his doctorate work-ing with Professor W. Todd Wipke at UC-Santa Cruz, followed by post-doctoral appointments at the MIT Artificial Intelligence Lab and the University of Michigan Cognitive Science Lab. Dr. Rogers has since published on a wide range of topics, including compu-tational chemistry, neural networks, statistics, brain research, and genetic algorithms. To register for any of the following seminars, call Molecular Simulations Inc. at (617) 229-9800, extension 567 in the U.S. In Europe, call +44 223 413302, extension 31.