Calcium channels
Is anyone aware of studies (or will share their own) which deal with the
structure of calcium channels? Our literature searches have given many
references to (Q)SAR of calcium agonists/antagonists, but none of the
papers appears to extrapolate from the immediate question to inferences
about the (local) structure of the binding site, much less the total
structure.
If there are no known (ultra)structural studies, a pointer to a reference
which addresses the question of receptor geometry and/or features inferred
from SAR of drugs would still be of interest.
I will summarize useful replies to the Net.
sb
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Stephen B. Bowlus, Ph.D. Computer-Aided Molecular Design
Research Division
e-mail: bowlus $#at#$ sandoz.com Sandoz Agro, Inc.
Phone: + 1 415 354 3904 975 California Ave.
Fax: + 1 415 857 1125 Palo Alto, CA 94304
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