binding pocket?

From: mmconn $#at#$ silibone.cchem.berkeley.edu (morgan conn)
Subject: binding pocket?
Date: Wed, 29 Nov 95 10:29:12 -0800

 Hello all;
 I'm looking for the impossible.
 If I have an inhibitor and a protein that are known to associate, and a set
 of mutations that appear to reduce the in vivo effects of this small molecule,
 is there a way to (reasonably) find a binding pocket for this molecule on the
 protein surface? The normal substrate for the molecule shows little, if any,
 structural similarity to the inhibitor, so the the substrate pocket would
 _not_ seem to be the binding site.
 Does anyone have experience/knowledge of this sort of thing.
 -morgan
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         Dr. M. Morgan Conn
         Department of Chemistry (Schultz group), UC Berkeley
         mmconn $#at#$ silibone.cchem.berkeley.edu
         510.642.9249; 510.643.6890 (fax)
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