Re: CCL:binding pocket?

From: hou -x- at -x- agouron.com (Xinjun Hou)
Subject: Re: CCL:binding pocket?
Date: Wed, 29 Nov 1995 13:29:21 -0800

 >If I have an inhibitor and a protein that are known to associate, and a set
 >of mutations that appear to reduce the in vivo effects of this small
 molecule,
 >is there a way to (reasonably) find a binding pocket for this molecule on
 the
 >protein surface? The normal substrate for the molecule shows little, if any,
 >structural similarity to the inhibitor, so the the substrate pocket would
 >_not_ seem to be the binding site.
 >
 >Does anyone have experience/knowledge of this sort of thing.
 Try DOCK.
 You can get more information on DOCK from
    http://cornelius.ucsf.edu/kuntz/dock.html
 C     Xinjun J. Hou (hou -x- at -x- agouron.com)      Agouron Pharmaceuticals,
 Inc.
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