cis/trans rotation barrier in peptides?

From: "Ed E. Moret" <E.E.Moret ( ( at ) ) pharm.uu.nl>
Organization: Utrecht University
Subject: cis/trans rotation barrier in peptides?
Date: Thu, 25 Nov 1999 11:22:01 +0100

 Hi CCL
 A question for the force field developers; I hope it is not a faq. It
 seems
 basic though.
 I would like to know what the experimental rotation barrier energy of
 the amide
 bond is in peptides of different composition? So, not just the readily
 accessible data on cis/trans isomerisation of prolines.
 If this is beyond measurement: has it been computed, taking into account
 solvation effects?
 With best regards
 Ed Moret
 --
 | Ed E. Moret	( ( ( at ) ) more ( ( at ) ) )	Department of Medicinal Chemistry
 | Faculty of Pharmacy	Utrecht University	The Netherlands
 | Tel.: +31 30 2536979(2536958)	Fax: +31 30 2536655
 | E-mail: E.E.Moret ( ( at ) ) pharm.uu.nl	WWW: http://wwwcmc.pharm.uu.nl/moret/