CCL:protein folding/sequence.

 Homology does not mean "amino acid  sequence similarity >20%" It is
 defined  in terms of functionality (cf. analogy). For a clear definition
 see Attwood, T. K. & Parry-Smith, D. J. (1999). Introduction to
 bioinfomatics (Cell and Molecular biology Series), Addison
 Wesley Longman Ltd., Harlow, England.
 Comparative modelling methods require more than  aligning protein
 sequences, constructing structural models against canonical quaternary,
 tertiary and secondary structural element templates  or using  threading
 methodologies and then minimisation. It is  increasingly  knowledge based,
 requiring more information on protein domain  motions (normal mode
 analysis), catalytic group analysis, protein-protein activation and
 modification, expression and regulation.
 For seminal papers perform  citation searches on the following
 publications and look for reviews that have used or criticised:
 Chou & Fasman (1978).  Advances in Enzymology, 47,  45-148
  Godzik et al (1993). J Computer-aided molecular design, 7, 397-438
 Jones et al (1992). Nature 358, 86-89
 Luthy et al (1992). Nature 356, 83-85
 Mosimann et al (1995).  Proteins 23, 301-317
 Novotny et al (1988). Proteins 4, 19-30
 good luck
 James Smith
 > ?I hear that if two sequences have homology (biological sequence
 > similarity)
 > greater than 20%, then their 3-d structures will be almost identical.
 >
 > Is this true? If so, can someone point me to some seminal papers
 > discussing
 > this...
 >
 > Thanks in advance. I will summarize if enough interest is shown.
 >
 > Best Wishes, Iraj.
 >
 _________________________________________________________________________
  James Smith       The Drug Design Group         01123 331 987 (Office)
  St.John's College Department of Pharmacology    01223 331 740 (Fax)
  Cambridge         University of Cambridge       07625 395 084 (Pager)
  CB2 1TP           CB2 1QJ                       js252 at.at cam.ac.uk
  United Kingdom    United Kingdom        http://www.cus.cam.ac.uk/~js252
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