Re: CCL:prions



Iraj Daizadeh wrote:
 >
 > Dear CCL.
 >
 > I was wondering what computational work
 > has been performed in prions. A project
 > on this is of most relevance due to the
 > mad cow follies...
 >
 > Any thoughts?
 >
 > Thanks, Iraj.
 >
 Hi, as I know, there are a couple of molecular dynamics simulations done
 on prion protein:
    Billeter M, Wuthrich K
      The prion protein globular domain and disease-related mutants
 studied by molecular dynamics simulations
      ARCH VIROL 251-263 Suppl. 16 2000
    Zuegg J, Gready JE
      Molecular dynamics simulation of human prion protein including both
 N-linked oligosaccharides and the GPI anchor
      GLYCOBIOLOGY 10: (10) 959-974 OCT 2000
    Zuegg J, Greedy JE
      Molecular dynamics simulations of human prion protein: Importance
 of correct treatment of electrostatic interactions
      BIOCHEMISTRY-US 38: (42) 13862-13876 OCT 19 1999
 Hope helpful,
 Yun
 --
 ***********************************************************
 Dr. Yun TANG
 Laboratory of Medicinal Chemistry
 NCI-FCRDC, Building 376, Room 205A        Tel: 301-846-5974
 376 Boyles Street                         Fax: 301-846-6033
 Frederick, MD 21702           E-Mail: yuntang-0at0-helix.nih.gov
 ***********************************************************