Protease Inhibitors Entropy/Enthalpy

From: David Turner <dturner -AatT- syntem-sa.fr>
Organization: Computational Drug Design, Syntem
Subject: Protease Inhibitors Entropy/Enthalpy
Date: Fri, 23 Feb 2001 09:37:48 +0100

Hi
 Can anybody point me to an article or articles discussing the
 relative contributions of entropic and enthalpic terms to the
 free energy of binding of substrates and/or inhibitors of HIV
 protease or perhaps in more general terms for aspartic and the
 various other classes of proteases?
 Thanks
 Dave
 --
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 David Turner                                             Synt:em
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