DOCK and chirality



I am using DOCK 4 for studying docking of certain molecules which are
 stereoisomers( D and L) and experimentally it was known that only one of
 the isomer is active.What protocol I should use when handling such
 molecules? I would like to know whether  DOCK can consider the chirality
 during calculation? I have tried using auto-match as well as manual
 match (with node maxi =4)  with grid based energy scoring method (rigid
 docking) but I have not found distinguishable results out of it.Can
 anyone suggest some solution for this particular type of problem?
 Thank you.
 Meena