Amber94 force field parameters for Saquinavir, Indinavir



 Hi,
 
I am using Konrad Hinsen's Molecular Modeling Toolkit to estimate changes caused by mutations in the HIV genome in the binding energy between the HIV protease and the Indinavir and Saquinavir protease inhibitors. Using Modeller, I can create PDB files with the estimated structure of a mutated HIV protease complexed to the protease. To calculate the interaction energy, I would need the Amber94 force field parameters for the inhibitor. Are such parameters available somewhere? I didn't find them on the Amber web site, though I would think that Indinavir and Saquinavir are well-studied molecules. Is it possible to mock up the interaction between the protease and the inhibitor? Something quick and dirty is fine for what I am doing.
 Many thanks in advance,
 Michiel de Hoon,
 Univsersity of Tokyo.
 --
 Michiel de Hoon, Assistant Professor
 University of Tokyo, Institute of Medical Science
 Human Genome Center
 4-6-1 Shirokane-dai, Minato-ku
 Tokyo 108-8639
 Japan
 http://bonsai.ims.u-tokyo.ac.jp/~mdehoon