CCL: query reg. docking followed by Dynamics

["Kalyan chaitanya" <kalyanpulipaka^-^gmail.com>]

Hi all,

I have a doubt, I am now working on Docking and i learnt that M.Dynamics and simulations would be very useful and efficient way of understanding how exactly two molecules are interacting with each other, i have GROMACS, TINKER and NAMD for the same purpose, but can you tell me-

1. Is it that we can see ligand and receptor coming together and trying to fit with different conformations and finally binding itself with a stable conformation.

2.can any one refer any publication papers who have done Docking followed by Dynamics and simulations in showing the interactions.

3. how relaiable is M.Dynamics and simulations.

Thanks in advance,

Regards,

P.Kalyan