From owner-chemistry@ccl.net Wed Jun  4 14:35:00 2008
From: "Michael Xu michael.drug.design ~~ gmail.com" <owner-chemistry#%#server.ccl.net>
To: CCL
Subject: CCL: agonist-antagonist-inhibitor
Message-Id: <-37092-080604122539-8172-jGbjy0dc6nQ7fnf+gCRD1A#%#server.ccl.net>
X-Original-From: "Michael Xu" <michael.drug.design#%#gmail.com>
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Date: Wed, 4 Jun 2008 11:29:12 -0400
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Sent to CCL by: "Michael Xu" [michael.drug.design#,#gmail.com]
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Hi, all



Recent days, some experts gave a wonderful explanation of IC50, Ki, Kd, and
deltaG.



I am confused about some words several years. Can anyone give some
discussion?



Inhibitor

Agonist

Antagonist

Inverse agonist.



Is the inhibitor used for Enzyme-substrate-inhibitor?

And the agonist/antagonist used for protein-ligand?



Thanks in advance.



Mike.

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<p class="MsoPlainText" style="MARGIN: 0in 0in 0pt"><font size="3"><font face="Consolas">Hi, all</font></font></p>
<p class="MsoPlainText" style="MARGIN: 0in 0in 0pt"><span style="COLOR: black"><font face="Consolas" size="3">&nbsp;</font></span></p>
<p class="MsoPlainText" style="MARGIN: 0in 0in 0pt"><span style="COLOR: black"><font size="3"><font face="Consolas">Recent days, some experts gave a wonderful explanation of IC50, Ki, Kd, and deltaG.</font></font></span></p>

<p class="MsoPlainText" style="MARGIN: 0in 0in 0pt"><span style="COLOR: black"><font face="Consolas" size="3">&nbsp;</font></span></p>
<p class="MsoPlainText" style="MARGIN: 0in 0in 0pt"><span style="COLOR: black"><font size="3"><font face="Consolas">I am confused about some words several years. Can anyone give some discussion?</font></font></span></p>
<p class="MsoPlainText" style="MARGIN: 0in 0in 0pt"><span style="COLOR: black"><font face="Consolas" size="3">&nbsp;</font></span></p>
<p class="MsoPlainText" style="MARGIN: 0in 0in 0pt"><span style="COLOR: black"><font size="3"><font face="Consolas">Inhibitor</font></font></span></p>
<p class="MsoPlainText" style="MARGIN: 0in 0in 0pt"><span style="COLOR: black"><font size="3"><font face="Consolas">Agonist</font></font></span></p>
<p class="MsoPlainText" style="MARGIN: 0in 0in 0pt"><span style="COLOR: black"><font size="3"><font face="Consolas">Antagonist</font></font></span></p>
<p class="MsoPlainText" style="MARGIN: 0in 0in 0pt"><span style="COLOR: black"><font size="3"><font face="Consolas">Inverse agonist. </font></font></span></p>
<p class="MsoPlainText" style="MARGIN: 0in 0in 0pt"><span style="COLOR: black"><font face="Consolas" size="3">&nbsp;</font></span></p>
<p class="MsoPlainText" style="MARGIN: 0in 0in 0pt"><span style="COLOR: black"><font size="3"><font face="Consolas">Is the inhibitor used for Enzyme-substrate-inhibitor?</font></font></span></p>
<p class="MsoPlainText" style="MARGIN: 0in 0in 0pt"><span style="COLOR: black"><font size="3"><font face="Consolas">And the agonist/antagonist used for protein-ligand?</font></font></span></p>
<p class="MsoPlainText" style="MARGIN: 0in 0in 0pt"><span style="COLOR: black"><font face="Consolas" size="3">&nbsp;</font></span></p>
<p class="MsoPlainText" style="MARGIN: 0in 0in 0pt"><span style="COLOR: black"><font size="3"><font face="Consolas">Thanks in advance.</font></font></span></p>
<p class="MsoPlainText" style="MARGIN: 0in 0in 0pt"><span style="COLOR: black"><font face="Consolas" size="3">&nbsp;</font></span></p>
<p class="MsoPlainText" style="MARGIN: 0in 0in 0pt"><span style="COLOR: black"><font size="3"><font face="Consolas">Mike. </font></font></span></p>

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