CCL: SYBYL-X 1.0 release now available, Windows and Linux
- From: "lei wang" <lwang,,tripos.com>
- Subject: CCL: SYBYL-X 1.0 release now available, Windows and
Linux
- Date: Mon, 26 Oct 2009 12:15:38 -0400
Sent to CCL by: "lei wang" [lwang . tripos.com]
SYBYL-X 1.0 is now available for all supported SYBYL customers. SYBYL-X
represents the next generation of the SYBYL suite, with availability on Windows
XP as well as on Linux RHEL 4, including all of the robust science available in
the original program coupled with improvements in user experience.
Enhancements in SYBYL-X 1.0 include release of a new workflow for ligand
preparation, allowing users to prepare molecular structures in the chemical
representation that is appropriate for submission to a variety of ligand-based
design applications, such as docking and topomeric studies. SYBYL also has a
new look, as the text console is now docked into the main window. The console
and toolbars can be undocked and moved to any location. Navigation within the
menu system and dialogs has been simplified.
SYBYL has been redesigned to better support task flow in a number of areas,
including atom and bond selection and bond expression definition. The UNITY
menu has been reorganization to match user task flow, and the SYBYL Sketcher is
now driven by a set of toolbars. The Systematic Search dialog has been
redesigned to include multiple tabs, providing easy access to all conditions for
the run.
Surflex-Dock enhancements include the addition of two major new modes: scoring
function optimization and multi-structure docking (multiple protein
conformations for a single target). In addition, protein pocket flexibility
has been added as an experimental option for rescoring docked poses as well as
in the final stages of the new mdock_list command.
Customers with valid support contracts can download SYBYL-X 1.0 from
www.tripos.com/download in the SYBYL section after creating an appropriate
profile on the tripos.com website that includes their address and the host id
for their SYBYL installation.