From owner-chemistry@ccl.net Fri Oct 29 04:25:00 2010
From: "Matt Segall matt.segall{}optibrium.com" <owner-chemistry_+_server.ccl.net>
To: CCL
Subject: CCL: New Paper: Making Priors a Priority
Message-Id: <-43032-101029042158-6597-lSavQdbgNqz9rAZl5pJVWQ_+_server.ccl.net>
X-Original-From: "Matt  Segall" <matt.segall()optibrium.com>
Date: Fri, 29 Oct 2010 04:21:57 -0400


Sent to CCL by: "Matt  Segall" [matt.segall---optibrium.com]
A new paper, "Making Priors a Priority" addresses a key challenge the community 
needs to address to get the most out of the predictive models we build. Just 
published on-line in J. Comp. Aided Mol. Design (DOI 10.1007/s10822-010-9388-
7), the paper discusses the question, "How useful will a model be in making a 
decision in a practical context?" To answer this requires an understanding of 
the prior probability distribution (the prior) and hence prevalence of 
negative outcomes due to the property being assessed.

The full paper can be downloaded from the Springer website at 
http://www.springerlink.com/content/x15h763770611316/ or a free preprint is 
available from the Optibrium on-line community at 
http://www.optibrium.com/community/publications/110-making-priors-a-priority.