From owner-chemistry@ccl.net Thu Oct 20 10:16:00 2011
From: "Sergio Manzetti sergio.manzetti(0)gmail.com" <owner-chemistry[-]server.ccl.net>
To: CCL
Subject: CCL: Nitrenium ion on the Guanosine base
Message-Id: <-45712-111020101231-10119-xiFyMKCToXs3CUpOIXFcjg[-]server.ccl.net>
X-Original-From: Sergio Manzetti <sergio.manzetti:_:gmail.com>
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Date: Thu, 20 Oct 2011 16:12:09 +0200
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Sent to CCL by: Sergio Manzetti [sergio.manzetti#,#gmail.com]
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Dear CCLrs, I am running some calculations on benzo[a]pyrene and its
qualities, but they do not seem to be familiar with other carcinogens,
although this is one of the most potent carcinogens. The mechanism of adduct
formation is delineated in the literature as a amine-epoxy mechanism, but
some issues do not compare well to this theory. Has anyone one this list
seen a reference or thought about that the guanosine base may undergo
ceonversion to a nitrenium-guanosine upon interaction with the epoxide or a
radical of the PAH?

Best wishes

Sergio

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Dear CCLrs, I am running some calculations on benzo[a]pyrene and its qualit=
ies, but they do not seem to be familiar with other carcinogens, although t=
his is one of the most potent carcinogens. The mechanism of adduct formatio=
n is delineated in the literature as a amine-epoxy mechanism, but some issu=
es do not compare well to this theory. Has anyone one this list seen a refe=
rence or thought about that the guanosine base may undergo ceonversion to a=
 nitrenium-guanosine upon interaction with the epoxide or a radical of the =
PAH?<br>
<br>Best wishes<br><br>Sergio<br>

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