From microsim@nis.net Mon Sep 16 23:38 EDT 1996
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Date: Mon, 16 Sep 1996 23:40:59 -0700
From: Willie Cui 
Organization: MicroSimulations
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Subject: Product Announcement to CCL
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I would like to post an email to CCL to announce the release of two computational chemistry software products.

Should I send the anouncement to you or direct to Chemistry@www.ccl.net? Please advise.

Following is the anouncement.  If approperiate, please send to CCL ASAP.

================================================================
CONTACT: Weili Cui, Ph.D.
MicroSimulations
478 Green Mountain Road
Mahwah, NJ 07430
(201) 512-0486
info@microsimulations.com

MICROSIMULATIONS CORP. ANNOUNCES RELEASE OF SOFTWARE
TO CREATE, ANALYZE AND EVALUATE 3D CHEMICAL STRUCTURES
ON DESKTOP COMPUTERS

MAHWAH, New Jersey-August 28, 1996-MicroSimulations Corp., an exciting new
innovator of molecular design, visualization, and analysis software, today announced
it's ChemInfo 3D family of applications to build, visualize, and analyze molecular
structures and associated functionality that will enable chemists to accelerate the
discovery process.

The first two products from this series, AccuModel and PowerFit, are released today.
A number of products are in beta test and will be released this fall, including
Property3D for calculating molecular properties based on 3D structures, BioPad for
protein sequence drawing and display, and PowerDock for molecular docking.

"The features in AccuModel 1.0 give chemists the capability to build, view and
analyze chemical structures on their PC or PowerPC desktop," said Weili Cui,
Director, Product Development. "For example, the chemist can build a structure
using the fragment library, or can import 2D drawings from ISIS/Draw or ISIS/Base.
The drawing can be converted automatically into 3D, and can be viewed in wire-frame,
ball-stick, and CPK models. Analysis features include distance , bond angle, and torsion
measurements."

Cui adds, "Moreover, the chemist can activate the MM3 force field to enable quick and
accurate structural optimization." MM3 was developed by Prof. Norman Allinger,
University of Georgia, and is widely accepted as the most accurate molecular mechanics
force field.

Complementary to AccuModel, PowerFit enables the chemists to "fit", or compare,
one structure to another. Manual or automated, rigid-body or conformational
flexible fitting. The fitting potential is based on the work of Kearsley and Smith and
known as "Steric and Electrostatic ALignment (SEAL).

Cui states, "Chemists can actually observe the "fitting" process which greatly
enhances their knowledge of the molecular similarity." Molecules can be controlled
manually for detailed visual comparison.

Designed for pharmaceutical and biotechnology companies, ChemInfo 3D desktop
system enables medicinal chemists to visualize, analyze and evaluate chemical
structures and is essential to efficient, productive molecular research.

AccuModel and PowerFit are for use on Windows (3.x, 95), Windows NT, and
PowerPC and are available for immediate delivery.

For more information, please visit MicroSimulations' Web site,
http://www.microsimulations.com

About MicroSimulations

Established in 1993, MicroSimulations Corp. offers an exciting suite of integrated
molecular design, visualization, and analysis software used in pharmaceutical,
chemical, agrochemical, and biotechnology research and development.
MicroSimulations' innovative products enable individuals, research teams, and
organizations to leverage intellectual assets by allowing scientist to enhance their
intuition through the use of powerful yet highly cost-effective applications designed to
speed new product discovery.

# # #

AccuModel and PowerFit are trademarks of MicroSimulations Corp. ISIS is a
registered trademark of MDL Information Systems, Inc. All other products are
trademarks or registered trademarks of their respective holders.

-- 
Willie Cui, Ph.D.
Director of Product Development
MicroSimulations
478 Green Mountain Road
Mahwah, NJ 07430
voice: (201)512-0486
fax:   (201)512-0489
http://www.microsimulations.com

From microsim@nis.net Tue Sep 17 00:15 EDT 1996
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Date: Tue, 17 Sep 1996 00:17:34 -0700
From: Willie Cui 
Organization: MicroSimulations
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Subject: AccuModel,  An Intuitive Program for Creating Accurate 3D Models Using the MM3 Force Field
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MICROSIMULATIONS CORP. ANNOUNCES THE RELEASE OF ACCUMODEL,
THE FIRST PRODUCT OF THE CHEMINFO-3D FAMILY OF SOFTWARE TO CREATE, 
ANALYZE AND EVALUATE 3D CHEMICAL STRUCTURES ON DESKTOP COMPUTERS

MAHWAH, New Jersey-August 28, 1996-MicroSimulations Corp., an exciting new
innovator of molecular design, visualization, and analysis software, today announced
it's ChemInfo 3D family of applications to build, visualize, and analyze molecular
structures and associated functionality that will enable chemists to accelerate the
discovery process.

The first product from this series, AccuModel, are released today. 
Another product, PowerFit, will be introduced in another posting.
A number of products are in beta test and will be released this fall, including
Property3D for calculating molecular properties based on 3D structures, BioPad for
protein sequence drawing and display, and PowerDock for molecular docking.

The features in AccuModel 1.0 give chemists the capability to build, view and
analyze chemical structures on their PC or PowerPC desktop. The chemist 
can build a structure using the fragment library, or can import 2D drawings from 
ISIS/Draw or ISIS/Base. The drawing can be converted automatically into 3D, 
and can be viewed in wire-frame, ball-stick, and CPK models. Analysis features 
include distance, bond angle, and torsion measurements.

Moreover, the chemist can activate the MM3 force field to enable quick and
accurate structural optimization. MM3 was developed by Prof. Norman Allinger,
University of Georgia, and is widely accepted as the most accurate molecular mechanics
force field.

Designed for pharmaceutical and biotechnology companies, ChemInfo3D desktop
system enables medicinal chemists to visualize, analyze and evaluate chemical
structures and is essential to efficient, productive molecular research.

AccuModel is for use on Windows 95, Windows NT, and
PowerPC and are available for immediate delivery.

For more information, please visit MicroSimulations' Web site,
http://www.microsimulations.com

-- 
Willie Cui, Ph.D.
Director of Product Development
MicroSimulations
voice: (201)512-0486
fax:   (201)512-0489
http://www.microsimulations.com

From microsim@nis.net Tue Sep 17 00:31 EDT 1996
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Message-ID: <323E5434.5DF5@nis.net>
Date: Tue, 17 Sep 1996 00:33:08 -0700
From: Willie Cui 
Organization: MicroSimulations
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To: chemistry@www.ccl.net
Subject: PowerFit, An Powerful Program for Molecular Fitting
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MICROSIMULATIONS ANNOUNCES RELEASE OF POWERFIT,
AN POWERFUL PROGRAM FOR MOLECULAR FITTING.

MAHWAH, New Jersey-August 28, 1996-MicroSimulations Corp., an exciting 
new innovator of molecular design, visualization, and analysis software,
today announced the release of PowerFit, the second product from it's
ChemInfo 3D family of applications.

The first product from this series, AccuModel, is designed for the construction
of accurate 3D molecular models using the MM3 Force Field and is introduced 
in a seperate posting. 

Complementary to AccuModel, PowerFit enables the chemists to "fit", or compare,
one structure to another. Manual or automated, rigid-body or conformational
flexible fitting. The fitting potential is based on the work of Kearsley and Smith and
known as "Steric and Electrostatic ALignment (SEAL).

The global search of the best fit is enabled using Monte Carlo simulated annealing
The user interface is very visual and intuitive. Molecules can be controlled
manually for detailed visual comparison. User can actually observe the dynamic "fitting" 
process.

Designed for pharmaceutical and biotechnology companies, ChemInfo 3D desktop
system enables medicinal chemists to visualize, analyze and evaluate chemical
structures and is essential to efficient, productive molecular research.

PowerFit is for use on Windows 95, Windows NT, and
PowerPC and is available for immediate delivery.

For more information, please visit MicroSimulations' Web site,
http://www.microsimulations.com

About MicroSimulations

Established in 1993, MicroSimulations Corp. offers an exciting suite of integrated
molecular design, visualization, and analysis software used in pharmaceutical,
chemical, agrochemical, and biotechnology research and development.
MicroSimulations' innovative products enable individuals, research teams, and
organizations to leverage intellectual assets by allowing scientist to enhance their
intuition through the use of powerful yet highly cost-effective applications designed to
speed new product discovery.

-- 
Willie Cui, Ph.D.
Director of Product Development
MicroSimulations
478 Green Mountain Road
Mahwah, NJ 07430
voice: (201)512-0486
fax:   (201)512-0489
http://www.microsimulations.com